ESOMEPRAZOLE
5-methoxy-2-{[(4-methoxy-3,5-dimethyl pyridine-2-yl)methyl]sulfinyl}-1-H-benzimidazole
Molecular formula
C17H19N3O3S
Molecular mass
345.4g/mol
Esomeprazole (inexium paranova) belongs to the class of organic compounds known as sulfinylbenzimidazole. It is the S- enantiomer of omeprazole. Sulfinylbenzimidazole are polycyclic aromatic compounds containing a sufinyl group.
Esomeprazole is sold as medicine under the brand name Nexium and is far more effective than its R-enantiomer omeprazole.
MEDICAL USUAGE OF ESOMEPRAZOLE
Esomeprazole belongs to the proton-pump inhibitors (PPIs) class of medicine . It performs gastric proton inhibitor activity. In parietal cells, esomeprazole is protonated and converted into the active achiral sulfenamide, which makes disulphide bonds with proton pump , hydrogen-potassium adenosine triphosphate (H+/K+ ATPase), hence inhabiting the secretion H+ ions of parietal cells into the gastric lumen . This inhibition of H+ ion secretion is done in the last step of acid
DISEASES CURED BY USING ESOMEPRAZOLE
Esomeprazole is used to treat the following diseases.
1. GERD( gastroesophageal reflux disease)
It is the backward flow of acid from the stomach causes heartburn and possible injury of the esophagus in adults oldersl and children 1 year of age. It is caused when lower esophageal sphincter( LES ) relaxes too often or for too long then, the backward movement of acid into esophagus causes heartburn. If GERD is left untreated, it lead to esphagitis and Barrett’s esophagus, a pre-cancerous condition. It’s symptoms include coughing, frequent clearing of the throat, difficulty in swallowing (dysphagia) , regurgitation of food or digestive fluids, hoarseness, or exacerbation.
2. Zollinger-Ellison Syndrome
It is the condition in which one or more tumors form in pancreas or the ipper part of your small intestine (duodenum).These tumors called gastrinomas secrete oarge amounts if gastrin hormone which Ultimate stimulates stomach to produce huge amount of gastric juice which Ultimately contains acid. The excessive gastric juice secretions which contains high amount of acid which then leads to pelvic ulcers,as well as diarrhea and other symptoms.
3. To prevent infection caused by the usage of NSAIDs
NSAIDs cause injury to the mucosa of the gastrointestinal tract from accute or kinor lesions to such as pectechia or erosions to more serious and chronic lesions such as ulcers, which lead to bleeding or perforation.
The infection caused by NSAIDs recover through a process called a restitution. If the damage don't penetrate muscularis mucosa,the infection can be cure in 1-3 days by proliferation and resteblishment of the glandular structures. Platelets play an important role in ulcer healing as they contain wide range of growth factors to which they deliver at the site of tissue damage.
4. To cure infection by H.pylori
Helicopterbectar pylori is a gram-negative bacterium that causes chronic infection in lower gastrointestinal tract I.e stomach and duodenum and is responsible for majority of peptic ulcers and chronic gastritis. Chronic gastritis is the inflammation of stomach lining which ultimately leads to stomach cancer. H.pylori secretes a cytotoxin A (Vac-A) which becomes the major cause of stomach cancer .
Qualitative and Quantitative Composition of esomeprazole
Nexium (esomeprazole) is available for oral administration as;
- Nexium capsules 20mg
Each capsule contains :
Enteric-coated pellets of Esomeprazole magnesium trihydrate equivalent to Esomeprazole…..20mg
- Nexium capsules 40mg
Each capsule contains ;
Enteric-coated pellets of esomeprazole magnesium trihydrate equivalent to esomeprazole,...40mg
